![]() ![]() ![]() Methods Twelve healthy volunteers received 60 mg prasugrel with placebo or 5 mg morphine intravenously in a randomized, double-blind, placebo-controlled, cross-over trial. Objectives To clarify whether more potent P2Y(12)-inhibitors may provide an effective alternative, we examined drug-drug interactions between morphine and prasugrel. ![]() Background Morphine decreases the concentrations and effects of clopidogrel, which could lead to treatment failure in myocardial infarction. ![]()
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